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III Symposium on the Effect of Chronic Hypoxia on Diseases at High Altitude

Dear Colleagues and friends:

Several colleagues were asking us about the next symposium.  It is here.

Mark you calendar for October 16-23, 2010!

The III Symposium on the Effect of Chronic Hypoxia
on Diseases at High Altitude
is coming up.
And yes, it will also be itinerant, so that conferences are carried out at different altitude sites:

click here to read about it.

Bolivia is waiting for you!

La Paz1

The city of La Paz at 3600 m.

Our previous two symposium were very succesful and everyone was able to appreciate not only the good science of the presentations, but also the visits to unique high altitude places.

II Symposium on the Effect of Chronic Hypoxia on Diseases at High Altitude (follow up)

We are at 39 years of scientific production in high altitude research, and we celebrate our friendship with you.

Due to unfortunate circumstances our Echocardiograph broke down and we are in need of a portable echocardiograph for high altitude research at 5300 m. Is there anyone that would know who would be so kind to donate such equipment and consequently collaborate to the sustainability of the high altitude medicine research and knowledge ? If any of you would like to participate in research with us, you are most welcome.

All the best from Bolivia.

Prof. Dr. Gustavo Zubieta-Calleja and     Prof. Dr. Gustavo Zubieta-Castillo (Sr)….. still active

High Altitude Pathology Institute
Web: AltitudeClinic.com
Email: zubieta@altitudeclinic.com
Phone: (591-2) 224-5394

A Refuge at the summit of Mt. Everest

It will be most convenient for the future Mt. Everest climbers, to have a refuge at the summit. For this purpose some explosive climbers experts should build a small cave that can house a small number of people, such that it will save lives by protecting those caught in severe storms. Life should be saved by all means. It can likewise be used as a laboratory for research at the extreme altitude of around 8800 m. Furthermore the cave could have an oxygen concentrator that could work on solar energy.

Prof. Dr. Gustavo Zubieta-Castillo.

Human Adaptation to High Altitude and Sea Level


Here goes the link (click below) to my dissertation that I have been repeatedly asked to publish on-line:

http://www.altitudeclinic.com/Copenhagen/Dissertation10b.pdf

It has novel things about adaptation of high altitude residents to sea level and future space travel. Hope you enjoy them.

The book is now available in all major libraries around the world.

For Example in Germany (click here):

or  in India: (click here)

Prof. Dr. Gustavo Zubieta-Calleja
High Altitude Pathology Institute
Celebrating our 39th Anniversary!!
Web: AltitudeClinic.com
Email: zubieta@altitudeclinic.com
Phone: (591-2) 224-5394

IPPA 39th Anniversary

High Altitude Pathology Institute
Clinica IPPA
Instituto de Patologia en la Altura

On July 2, 2009 we celebrated our 39th Anniversary at the Zubieta University Cafeteria. Several distinguished colleagues from important medical centers in La Paz, joined us in the celebration.

Gustavo Zubieta-Calleja Jr. (Clinica IPPA), Saul Pantoja (Hospital Obrero), Rafael Aramayo (Clinica Aranda), Martha Mejia (OMS/OPS) Cinthya Sempertegui (Cossmil), Gustavo Del Carpio (Hospital de Clinicas), Marco Antonio Rios Bravo (Centro Otorrino-Laryngologico Rios-Bravo), Gonzalo F. Soliz (Talentum Garden Clinic), Ricardo Ramos (Psiquiatria and Club Andino Boliviano), Percy Halker (OMS/OPS).


Gustavo Zubieta-Castillo (Clinica IPPA), Ricardo Amaru (Instituto de OncoHematologia), Eduardo Aranda (Hospital del Niño), Ignacio Alurralde (Banco de Sangre) and Mario Luis Tejerina (Clinica Del Sur) (last 4 from the “Sociedad de Hematologia”), Gustavo Zubieta-Calleja (Clinica IPPA), Franz Peter Freudenthal and Alexandra Heath (KardioZentrum).

The powerpoint presentation by Drs. Gustavo Zubieta-Calleja (Jr) and Gustavo Zubieta-Castillo (Sr) can be found here.

The Argentinian football team lost to Bolivia in La Paz, due to the high altitude fear factor

Gustavo Zubieta-Castillo the Director of the High Altitude Pathology Institute affirmed in a newspaper interview that the Argentinian Soccer team took its worst defeat in world Cup qualifying play, 6 – 1  to the Bolivian Soccer team in La Paz. due to “fear of high altitude”. He affirmed “The fear factor played a crucial role. Fear uses up more energy than physical exercise.”

Periodico LA PATRIA, ORURO, BOLIVIA Domingo 5 de Abril de 2009
Primera Plana.

Director del Instituto de Patología de la Altura, Gustavo Zubieta Castillo
SELECCION ARGENTINA PERDIO PORQUE TUVO MIEDO A LA ALTURA

•    Indicó que cuando se tiene miedo se gasta cualquier cantidad de energía, más que el esfuerzo físico

Los jugadores bolivianos siempre fueron más, en recuadro, Gustavo Zubieta Castillo

Prof. Dr. Gustavo Zubieta-CastilloLos jugadores bolivianos siempre fueron más, en recuadro, Gustavo Zubieta Castillo 

La selección de fútbol de la Argentina perdió el partido contra Bolivia, porque tuvo miedo a la altura, ya que si bien la altura afecta, pero sólo entre un 10 a 15 por ciento en el rendimiento de un deportista, sin embargo, el porcentaje restante, se debe al factor psicológico y la preparación táctica y técnica que puedan tener los jugadores.

Esa fue la afirmación que realizó ayer, el experto en problemas de la altura y director del Instituto de Patología de la Altura, Gustavo Zubieta Castillo,
quien estuvo presente en nuestra capital para hablar de ese tema tan polemizado, principalmente por los periodistas argentinos que convirtieron a la altura en un mal.

En una entrevista con LA PATRIA, el profesional afirmó: “Mucho se habla de la altura sin tener conocimientos que sean de carácter científico. A nivel mundial el tema de la altura tiene varios años y poco a poco, se fueron descubriendo las reacciones de manera normal del organismo a la altura y después me he dedicado al efecto de las enfermedades”, dijo.

No negó que la altura puede llegar a afectar e incluso esta puede ser mortal, pero en extremas condiciones, pese a que incluso un feto puede sobrevivir en el vientre de su madre a la altura del monte Everest, que está a 8.844 metros sobre el nivel del mar.

Indicó que hay personas que vienen (a nuestro país) después de un tiempo y se adaptan a la altura y hay gente que viene y si no se la atiende puede morirse por la altura, por edema cerebral, edema pulmonar, cosa que no debe ocurrir ahora porque esas enfermedades ya se las conoce y son curables.

“Ahora que la altura a los argentinos les ha afectado, sí les ha afectado, pero ese factor dentro del deporte que han realizado equivaldrá al 10% ó 15%, pero hay otro factor que no lo toman en cuenta, que es el temor a la altura, porque si usted tiene miedo, se le paran los pelos, se puede enfermar y hasta puede morirse de susto”, afirmó.


Argumentó que hay dos aspectos asociados a lo mencionado, uno es la altura y el otro es el susto a la altura.

Acotó que el director técnico de la selección Argentina, Diego Maradona quiso manejar el problema de la altura, pero lo subestimó.

“El otro porcentaje que es el 85% a 80%, es la capacidad física de los sujetos, la capacidad física de los sujetos, la técnica deportiva que utilizan, porque ellos teóricamente deberían ganar en el partido, pero se tropezaron con un equipo realmente extraordinario y le digo que el factor psicológico tiene tanta importancia, porque si usted nota en los nacionales, después del tercer gol tomaron confianza para meter el cuarto, quinto y sexto gol, por la confianza que tuvieron ellos en el juego”, indicó.

“Y lo contrario sufrió con los argentinos, que indudablemente sintieron el efecto de la altura, pero cuando ya tenían tres en contra, se desmoronó la cosa. Ahora el factor de la altura tuvo importancia en un 10 a 15 por ciento, pero a un equipo de esa naturaleza lo que le afectó fue el temor a la altura, porque cuando se tiene miedo, es cuando existe un desgaste de energía tremendo, entonces, ha sido el temor a la altura y el temor a perder el partido, y su comportamiento ha sido un desastre”, puntualizó.

From: http://lapatriaenlinea.com/index.php?option=com_content&task=view&id=2967&Itemid=92

Life is possible at the hypoxic levels of the summit of Mt. Everest

Photo from Wikipedia
Revisiting the original theory by Prof. Dr. Gustavo Zubieta-Castillo that it is possible for man to adapt to live even on the highest mountain on planet Earth: Mt. Everest, please find below links to:

1) The original paper as published in the Fiziol. Journal 2003, 49:3, pg. 110-117

2) A Chapter of the book: Adaptation Biology and Medicine (Volume 5:Health Potentials).

3) An attempt by three bold and extraordinary Nepalese brothers to remain atop Everest for 24 hours:

http://news.bbc.co.uk/2/hi/south_asia/7892588.stm

It is a first step in the proof of these bold theories, in spite of incomplete or rather “insufficient” time for full adaptation.

New publications on ophthalmological studies and altitude adaptation

The effect of High to Low Altitude Adaptation on the

Multifocal Electroretinogram.

Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
High Altitude Pathology Institute, La Paz, Bolivia; Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark

PURPOSE. To examine variations in retinal electrophysiology assessed by multifocal electroretinogram (mfERG) during acclimatization of native highlanders during adaptation to normobaric normoxia at sea level. METHODS. Eight healthy residents of from the greater La Paz area in Bolivia (3600 m above sea level) were examined over 72 days after arriving in Copenhagen, Denmark (sea level). A control group of 8 healthy lowlanders was used for comparison. RESULTS. During the period of observation hemoglobin decreased from 16.7 gm/dL to 15.0 gm/dL (p = 0.0031), erythrocytes decreased from 5.3 T/l to 4.6 T/l (p = 0.0006), and hematocrit decreased from 49.4% to 42.2% (p = 0.0008). At baseline, Day 2 after arrival, the amplitudes (N1, P1, N2) of the mfERG were 43.1-59.9% higher in the highlanders than in lowlanders (p < 0.017). During acclimatization the mfERG amplitudes increased 16.9 to 20.4% (p < 0.028) to a level 73.2-87.0% higher in the highlanders than in lowlanders (p < 0.0008). The increase in amplitude was inversely proportional to the decrease in erythrocyte concentration (p = 0.023, 0.053, 0.12 for N1, P1, N2 respectively). CONCLUSIONS. Upon arrival at sea level, highlanders had markedly supernormal multifocal electroretinographic amplitudes that continued to increase during the 72 day period of observation where the highlanders’ hematocrit normalized. Our results suggest that acclimatization after a change in altitude and hence in ambient oxygen tension involves intrinsic retinal mechanisms and that acclimatization had not been completed at the end of the study.

Invest Ophthalmol Vis Sci. 2009 Feb 21.

extracted from:

http://www.ncbi.nlm.nih.gov/pubmed/19234353

L’Internaute website: Football at 6542 m

The website L’Internaute Sport has published a series of
incredible Sports experiences.

Among them:

floating tennis courts,
marathon in space,
tennis heliport in Dubai,
mountain biking,
golf on snow,
tennis on top of water,
Ski in the dessert,
Cricket in the Himalayas,
tennis in a boat
and the football (soccer) game played on the summit of Mt. Sajama at 6542 m. that the High the Altitude Pathology Institute organized in August 2001.

Click here to view the photos.

Click here to read about the Sajama football game.

Article of the AIPS regarding the FIFA’s high altitude soccer limitations

FIFA’s high altitude decision “a violation of rights”

Nemesio Camacho el Campín Stadium, Bogotá, Colombia

By Oscar Munevar Forero
Acord Colombia

The decision taken by FIFA president Joseph S. Blatter, to suspend the matches played at an altitude higher than 2,500 meters above sea level, violates the Association’s rights, in particular the South American associations. The Olympic stadium Hernando Siles Suazo of La Paz (capital of Bolivia), the Olympic stadium Atahualpa of Quito (capital of Ecuador) and the stadium Nemesio Camacho el Campín of Bogotá (capital of Colombia) that are at altitudes of 3576, 2850 and 2600 meters above sea level, respectively, are the most affected by the decision taken by the “tsar” of the football world.

We looked for opinions from some experts such as Dr. Gustavo Zubieta Castillo, who is the author of an article on this subject entitled “Pulmones y altura: funcion respiratoria y adaptación” (The lungs and high altitude: respiratory function and adaptation.

It is stated in the introduction that “No animal species ascends beyond its endurance capacity and above its genetic security conferred by the nature. For humans, however, altitude has always represented a challenge. His eagerness to conquer all the surroundings, to prove and increase his endurance, overcome any barrier or obstacle. One of the bigger constraints is undoubtedly acute exposure to hypoxia. The organism has to overcome this reduction in environmental oxygen pressure by involving many mechanisms in order to reach its target: the supply of enough oxygen to the tissues”.

As we know, high altitude training makes athletes perform better. As Zubieta Castillo said: “when a perfect adaptation is needed, the human body reacts accordingly”.

The Bolivian scientist adds: “The mechanisms of adaptation, in relation to time, have two stages: acute adaptation and chronic adaptation. Acute adaptation is manifested by a big energy expenditure directly related to the level of high altitude. The decrease of the atmospheric air pressure is compensated for by the pneumodynamic pump, that gives rise to a fast air renewal: increase of the respiratory frequency (RF) and the tidal volume (VT). The hemodynamic pump increases proportionally the blood flow to the lungs: increase of the cardiac frequency (CF) and the systolic volume (VS). Both mechanisms are readily observed but require a complex neurohumoral control. The changes occur in different systems, binding oxygen to hemoglobin and eliminating the carbonic anhydride, at a normal pH 7.40.”

Therefore, all seems to indicate that FIFA took the decision without thinking it through. Few people are affected by the decision, but it benefits many more.
However, no survey has been carried out proving that playing at high altitude affects the human body. What is evident is once again the fear of the big countries of South America (Argentina, Brazil, Uruguay, and Paraguay) to face smaller countries.

A serious study should be carried out in order to reach a balance, otherwise the stadiums of Colombia, Ecuador, Bolivia and the countries themselves are almost obliged to disappear. The football fans of those countries are censored, violating the right of equality.
For the full Spanish text please click here.

from:
http://www.aipsmedia.com/index.php/index.php?page=news&cod=1185&tp=n