And about disease at high altitude?
High Altitude Pulmonary and Pathology Institute IPPA
La Paz, Bolivia

And about disease at high altitude?
La Paz, Bolivia

RELAMI Altura, Octubre 2015. (English version below)
HOMENAJE GUSTAVO ZUBIETA-CASTILLO
1926-2015
Homenaje “In Memoriam”
A la Familia y a su hijo Dr. Gustavo Zubieta Calleja (La Paz – Bolivia) del Ilustre y Honorable Profesor Dr. Gustavo Zubieta-Castillo MD (20 mayo 1926 a 17 septiembre 2015, 89 años) médico boliviano, experto en medicina de altitud, fisiólogo, cirujano militar, escritor, pintor, nombrado como el “Gurú de la montaña” en el Colegio Médico de San Juan en Bangalore, India (1).
Ha trabajado en fisiología de alta montaña. Nació a 3800m en Oruro, Bolivia, y después de estudiar medicina en la Universidad Mayor de San Andrés en la ciudad de La Paz, a 3.513 m sobre el nivel del mar, enfoco todo su trabajo a temas de fisiología en alta montaña y más tarde evolucionó al estudio de la patología derivada de la altitud. Propuso nuevos conceptos y la comprensión de lo que se conoce como la Enfermedad Crónica de Montaña. Esta patología objetivada a gran altura, con cifras por encima de los valores normales para tales altitudes, se caracteriza por un aumento del número de glóbulos rojos, cianosis, fracaso ventilatorio y alteraciones respiratorias con hipertensión pulmonar e hipertrofia del ventrículo derecho, que inicialmente se afirmaba que se debía a “la pérdida de la adaptación”. El profesor Gustavo Zubieta Castillo cambió esta interpretación, y el estaba firmemente convencido de que: “Los sistemas orgánicos de los seres humanos y de todas las demás especies tienden a adaptarse a cualquier cambio ambiental y circunstancias en un período óptimo de tiempo, y nunca tienden a la regresión lo que conduciría inevitablemente a la muerte” (2). Este concepto ha cambiado la forma en como se interpretan las enfermedades de gran altitud.
El 9 de julio de 1970, Zubieta-Castillo funda la primera clínica de gran altura en el mundo y que se encuentra en La Paz, Bolivia, denominada “Instituto de Patología en la Altura”. Una de sus teorías es que el hombre tiene la extraordinaria capacidad de adaptación a vivir en un ambiente hipóxico incluso en el punto más alto del planeta Tierra: la cumbre del monte Everest de 8842m (3).
Por tanto; es para nosotros, la América Andina agrupada en la “Red Latinoamericana de Investigación de Medicina Intensiva en la Altura” – RELAMI-Altura, ofrecer este homenaje póstumo a tan ilustre colega y profesor boliviano, mostrar nuestro agradecimiento por haber tenido el honor de compartir momentos de sublime aprendizaje, y por marcar el sendero a seguir en la Medicina en la Altura.
Atentamente
PRIMERA JUNTA DIRECTIVA
Dr. Manuel Jibaja Vega. COORDINADOR GENERAL,
Dr. E. Enrique Maraví Poma.COORDINADOR EUROPA.
Dr. José Antonio Carmona Suazo. COORDINADOR MÉXICO.
Dr. Guillermo Ortiz Ruiz. COORDINADOR COLOMBIA
Dr. Ignacio Vladimir Granda Luna. COORDINADOR ECUADOR.
Dr. Amilcar Tinoco Solórzano. COORDINADOR PERÚ.
Dr. Freddy Sandi Lora. COORDINADOR BOLIVIA.
HOMAGE GUSTAVO ZUBIETA-CASTILLO
1926-2015
IN MEMORIAM
To the family and his son Dr. Gustavo Zubieta-Calleja (La Paz, Bolivia) of the Illustrious Honorable Professor Dr. Gustavo Zubieta-Castillo MD (May 20 1926 to September 17, 2015, 89 years old) bolivian physician, high altitude medicine expert, physiologist, military surgeon, writer, painter, named the “Mountain Guru” at the Medical College of Saint John’s in Bangalore, India (1).
He worked in high altitude physiology. Born at 3800m in Oruro, Bolivia and after studying medicine in the Universidad Mayor de San Andres in the city of La Paz, at 3513m above sea level, he focused all his work on high altitude physiology and later evolved to the study of pathology resulting from high altitude. He proposed new concepts and the understanding of what is known as Chronic Mountain Sickness. This pathology observed at high altitude, with values above the normal ones for such altitude, is characterized by an increase of the number of red blood cells, cyanosis, ventilatory insufficiency and respiratory alterations with pulmonary hypertension and right ventricular hypertrophy, that was initially considered to “loss of adaptation”. Professor Gustavo Zubieta-CAstillo changed this interpretation and he was firmly convinced that “The organic systems of human beings and all other species, tend to adapt to any environmental change and circumstance in an optimal period of time, and never tend towards regression, which would unavoidably lead to death” (2). This concept has changed the way how disease is interpreted at high altitude.
On July 9th, 1970, he created the first high altitude clinic in the world, that is found in the city of La Paz, Bolivia with the name ” Instituto de Patología en la Altura” (‘High Altitude Pulmonary and Pathology Institute”). One of his theories is that man has the extraordinary capacity to adapt to live in a hypoxic environment even in the highest point on planet earth, the summit of Mt. Everest 8842m (3).
Consequently, it is for us, the Andean America gathered int the ‘Red Latinoamericana de Investigación de Medicina Intensiva, en la Altura” – RELAMI-Altura, (“Latin-American Network of High Altitude Intensive Care Research”) to offer this posthumous homage to such an illustrious Bolivian colleague and professor, showing our gratitude for having had the honor of sharing the sublime learning and for showing us the road to follow in High Altitude Medicine.
Referencias,
1. http://altitudeclinic.com/blog/2010/01/the-mountain-guru/
2. http://altitudeclinic.com/blog/2010/07/forever-loss-of-adaptation-does-not-exist/
3. Zubieta-Castillo G, Zubieta-Calleja GR, Zubieta-Calleja L, Zubieta-Castillo N (2008). “Facts that Prove that Adaptation to life at Extreme Altitude (8842m) is possible”. In Adaptation Biology and Medicine, Suppl 5: 348–355. Editors: L. Lukyanova, N. Takeda and P.K. Singal. Copyright © 2008 Narosa Publishing House Pvt. Ltd., New Delhi, India. 26.
“Spending the 90s”, as he used to affirm, Prof. Dr. Gustavo Zubieta-Castillo,


GRATITUDE
Gustavo Zubieta-Castillo
dedicated to:
James Muldrey, Professor of biochemistry, Tulane Medical School, USA.
Walter Unglaub, Dean, Tulane Medical School, USA
Rafael Rubio, Professor, Instituto de Cardiología de México
Skip Houser, Teacher and Director, USA
Thuppil Venkatesh, The Lead Man of India
and many that remain in our memory
.
We should not search for fault in those
who circumstantially crossed our path
and inflicted damage upon us,
because, in time, they will taste their own bitterness..
the weight of their flawed choices and wrong behavior.
.
Some may rise, become visible, even celebrated,
and wish for one’s disappearance,
from the spaces they now inhabit,
in order to erase bad memories,
because one was a witness to who they truly were.
It is strange how such profound human behavior
holds our attention only for a moment.
.
Human development
is a quiet, constant adaptation
shaped by experience and knowledge
a fragile effort to preserve a pleasant life
and a harmonious relationship with those around us.
Translation by Gustavo Zubieta-Calleja (Jr).
Dear colleagues and hypoxia friends:
We will be hosting the V Chronic Hypoxia Symposium in Bolivia this October 6-11, 2014. Several outstanding scientists from around the globe will join us to discuss tolerance to hypoxia, and other aspects of hypoxia. Among them we have Jan Marino Ramirez, Robert Naejle, Frantisek Kolar, S.V Srikrishna, Wolfgang Jelkmann, Thuppil Venkatesh, Praveen Sharma, Jain Neera, and several other outstanding scientists. The setting is an itinerant symposium where we will carry out the conferences at different altitudes. If interested, please let us know. Our philosophy is that everyone can participate openly. Some months prior to the meeting we will post some questions regarding our themes at ResearchGate.net in order to carry out and develop a virtual discussion that will end at the meeting itself. All participants will be invited to post questions here (if they wish), prior to their presentation here in La Paz. This will certainly focus all of us on our subjects of interest in a dynamic way.
http://www/zuniv.net/symposium5
so, come join us!
Dear friends and colleagues around the world!

click here to go to the Symposium website
Colleagues from many countries in the world are enthused and lined up to honor us with their presence.
It will once more be an itinerant symposium, where talks are given in different altitude sites. We will visit and have conferences at:La Paz 3510 m
Titicaca Lake, 3800 m
Tiahuanacu ruins 4000 m
Chacaltaya at 5230 m
and the Salt Lakes 3656 m
You will learn of “life at high altitude” in different environments.
And this time we are going to visit the famous Salt Lakes at 3656 m in the South of Bolivia (shown above).
Click here to read more about the Uyuni Salt lakes.You will be completely impressed by the beauty of Bolivia and the hypoxic environment that is our “normal” everyday life.
click here to read about it.
During the V Chronic Hypoxia Symposium, we will have a meeting of the
International Society of Chronic Hypoxia.
It was created during the II Chronic Hypoxia Symposium
We will discuss about Life in Extreme Hypoxia and the
Tolerance to Hypoxia Formula.
Is it true that the paradox of going higher renders more tolerance to hypoxia?
Great scientists will join us in the analysis of these and other fascinating topics, so don’t loose the chance
by clicking here.
We are going to celebrate 44 years of scientific production in high altitude research..
Please read of our latest events and activities at:
http://altitudeclinic.com/blog/
All the best from Bolivia!!
Prof. Dr. Gustavo Zubieta-Calleja and Prof. Dr. Gustavo Zubieta-Castillo (Sr)….. still active
High Altitude Pulmonary and Pathology Institute
43 years of high altitude medicine
Web: AltitudeClinic.com
Email: zubieta@altitudeclinic.com
Phone: (591-2) 224-5394
Abstract People living at sea level have poor tolerance to hypoxia. In striking contrast, humans experiencing hypoxia at high altitude live very well. How is it possible for man to tolerate extreme hypoxia at high altitude? In this article we propose a hypothesis that potentially explains the tolerance to hypoxia at high altitude. Close examination of values of hemoglobin and PaCO2 for an altitude of 3510 m demonstrate that an increase in hemoglobin (Hb) and a decrease in arterial carbon dioxide tension (PaCO2) are two essential changes that occur on high altitude exposure. We propose a formula :
We present evidence that the relationship between Hb and PaCO2 explains the tolerance to hypoxia at high altitude.
The Full published article PDF can be found here
Original citation: Gustavo R. Zubieta-Calleja, Gustavo Ardaya, Natalia Zubieta-De Urioste, Poul-Erik Paulev and Gustavo Zubieta-Castillo, http://altitudeclinic.com/blog/2013/04/tolerance-to-hypoxia/, April 10, 2013.
Formula originally published at: http://altitudeclinic.com/blog/2012/08/the-tolerance-to-hypoxia-formula/
Originally presented at LEH hypoxia symposium
at: http://altitudeclinic.com/blog/2012/09/the-lung-at-high-altitude/
The Lung at High Altitude: From cellular acclimatization to clinical disease
August 3-7, 2012
Leh, Ladakh, J&K, India
Prior to the Global Hypoxia Summit and 4th International Conference on Chronic Hypoxia held in India, the Leh Symposium was carried out under the direction of Dr. Qadar Pasha, the organizing secretary that efficiently carried this meeting. We were invited speakers thanks to Dr. QadarPasha and substantially Prof. Thuppil Venkatesh.

It was an atmosphere of science and friendship, with pleasant discussions on the many aspects motivating the search for knowledge in hypoxia. Leh is located at 3500 m of altitude quite similar to La Paz. It is over an hour flight from Dehli. I understand there are 27 flights per day so it is a very popular tourist destination.
And of course, where you experience hypoxia. The Pulmonary Vascular Research Institute (PVRI) also participated as coorganizer. Likewise, the Institute of Genomics and Integrative Biology under the direction of Dr. Rajesh S. Gokhale, based in Dehli and the Sonam Narboo Memorial Hospital in Leh, J&K, India with Dr. Ghulam Mohammad. He kindly had us visit the hospital premises.

Several members of the PVRI were present including Ghazwan Butrous who recorded the conferences live and these will be available for the Fellows of the PVRI on their website. We again met Prof. Dr. Max Gassmann of the University of Zurich, Switzerland. He presented his work on Erythropoietin’ impact on exercise performance. Noteworthy was the presence of Dr. Sheila G. Haworth of the UK. She gave an intersting talk about surviving birht ath any altitude, Hypoxaemia to Normoxaemia. Prof. Thuppil Venkatesh, proposed a novel idea of gene mixing to improve human performance.

Robert Naejle from Universite libre de Bruxelles, was very inquisite and critical about the presentations, which gave it a stimulating touch, that we personally greatly enjoyed! He talked about pulmonary disffusion and exercise physiology. Jose Lopez-Barneo, from Spain gave an interesting talk about about the effects of chronic hypoxia on peripheral and central neurogenic centers. We also enjoyed the comments of Rubin Tuder from Denver Colorado. He talked about pulmonary vasculature and hypoxia signaling. Hari S. Sharma gave a brief talk on Angiogenensis and tissue remodeling. Dr. Gabriel Diaz from the Universidad Nacional de Colombia, in Bogota, talked about the hyperreactivity of the pulmonary vascular tree. Anita Saxena from the All India Institute of Medical Sciences talked about the Eisenmenger syndrome.

We also made good friends with Uttam Patti, from the Nehru University who was presenting interesting work on hypoxia in cancer cells. And we also were plesantly surprised by the presence of our bolivina colleague Alexandra Heath from Kardiocentrum in La Paz, Bolivia. Her work on neonatal pulmonary circulation at high altitude was also very novel. We also heard some talks on CMS from Dr. Prakash, Negi, Dr. Norboo Angchuk and Dr. Tsering Norboo.

Gustavo Zubieta-Castillo (Sr) gave a talk on Adaptation to life at the summit of Mt. Everest, adding new information to his hypothesis. Gustavo Zubieta-Calleja (Jr), gave a conference on a complete novel concept: The Tolerance to Hypoxia Formula, affirming that the higher one goes, the more tolerance to hypoxia there is.
