Category Archives: Meetings

Hyaena Potosi Mountain near La Paz, (photo courtesy of Giuseppe MIsserochi)

6th Chronic Hypoxia Symposium Follow-up

Chronic Hypoxia Symposium VI – Follow-up

Oct 10 – 16, 2016
La Paz, Bolivia

Dedicated to the late Prof. Dr. Gustavo Zubieta-Castillo

Prof. Dr. Gustavo Zubieta-Castillo "The Mountain Guru"

Prof. Dr. Gustavo Zubieta-Castillo “The Mountain Guru”

This unique itinerant symposium was a gathering of participants from around the world, all sharing a common interest in the wonder of the mountain environments, whether through research or other endeavors. With Chairman Dr. Gustavo Zubieta-Calleja at the helm, assisted by his family, medical students and Dr. Fabian Wayar. This symposium convened in La Paz (3100 – 4100m), and was generously supported by the High Altitude Pulmonary and Pathology Institute (IPPA) with collaboration by the Bolivian Navy, the La Paz Medical College and its President, Dr. Luis Larrea and the Universidad Franz Tamayo “Unifranz.” All were engaged in the lively presentations, and were wholly encouraged to participate in topic discussions.

Details of the Conference

The conference presentations were given almost exclusively in English. Attendees met in the Unifranz on the first day on Monday Oct 10, 2016, where opening words were given by Prof. Dr. Gustavo Zubieta-Calleja, Director of the High Altitude Pulmonary and Pathology Institute (IPPA) and Dr. Thuppil Venkatesh, President of the International Society of Chronic Hypoxia. This symposium was poignantly dedicated in the memory of the incomparable Dr. Gustavo Zubieta-Castillo, whose life was devoted to the study of hypoxia and the care of patients suffering from altitude illness. A presentation by Dr. Zubieta-Castillo’s granddaughter, Natalia Zubieta, highlighted his life’s work. Conference participants were provided with books commemorating Dr. Zubieta-Castillo with quotes from colleagues who respected and admired him and his work from around the globe.

First day of conferences

First day of conferences

Dr. Giuseppe Miserocchi, former Professor of Physiology and Biophysics at the University Milano-Bicocca in Italy, gave an enlightening talk on the Inter-individual Differences in the Adaptive Response of the Lung to Hypoxia. Dr. Miserocchi described the conditions leading to lung edema, including miscrovascular permeability and increased cardiac output, versus the conditions opposing it, including interstitial matrix rigidity, vasoconstriction in pulmonary microcirculation, and reduced capillary patency. Variations exist among human response to diffusion capacity of the lungs during hypoxia, with more than half of the subjects showing an increase in alveolar membrane diffusing capacity that overpowered the decrease in lung capillary blood volume.

Dr. Zubieta-Calleja gave a lively presentation regarding The Road to “Defeating Hypoxia” is a timely exposure to chronic hypoxia. He also discussed polyerythrocythemia as a precise terminology developed by the late Prof. Dr. Gustavo Zubieta-Castillo, to be used instead of chronic mountain sickness. He reiterated the simple yet powerful formula:

Adaptation =  time / altitude

Dr. Zubieta-Calleja challenged the belief that people life’s under chronic hypoxia is debilitating, arguing that many conditions may be treated with exposure to hypoxia. He gave evidence of increased longevity among high-altitude dwellers. He punctuated his talk by climbing on a chair and “punching” hypoxia, breaking it into pieces that fell down in the screen, to emphasize its defeat!

A tour through the city of La Paz

A tour through the city of La Paz. Walter Calderon (Peru), Willy Cortez (Bolivia), K.V.R. Tagore (India), Naanjapa  Rajashepar (India), Satish Jain (India) , Sadashivaiha (India), Annie Wislowski (USA), Jose Antonio Carmona (Mexico), Benedito Machado (Brazil).

After several breaks, in which the conference attendees enjoyed tasty local cuisine such as salteñas, cunapes, and galletas, Dr. Benedito Honorio Machado from the School of Medicine of Riberao Preto in the University of Sao Paolo, Brazil presented “Neural Mechanisms Involved in Autonomic and Respiratory Changes in Rats Submitted to Short-Term Sustained Hypoxia.” In this talk, Dr. Machado described the role of short-term sustained hypoxia on anesthetized rats in increasing the sympatho-inhibitory and bradycardiac components of baroreflex, as well as the sympathetic and respiratory responses of peripheral chemoreflex. They found hypoxic exposure was associated with increased excitation of the nucleus tractus solitarius neurons on the carotid body and aortic depressor nerve. Changes in glial density were also noted.

Dr. Alla Portnychenko, Head of the International Centre for Astronomical, Medical and Ecological Research, NAS of Ukraine presented via webcam “Rebuilding of carbohydrate and lipid metabolism under hypoxia: Regularities and therapeutic possibilities.” Her studies on rats showed activation of hypoxia inducible factor 1a (HIF-1a) and -3 a subunits during hypoxia, resulting in the induction of GLUT-4 and -1 in the myocardium and lungs. This resulted in a change from carbohydrate to predominantly lipid substrate up-regulation. In humans, they found changes in cholesterol metabolism, leptin and insulin-growth factor IGF-1 plasma levels, and positive correlation with HIF-dependent protein IFG-1 and HDL-cholesterol. She concluded with the intriguing suggestion that hypoxia might be used to correct metabolic disorders in some people.

Dr. Zoya Serebroska of the Bogomoletz Institute of Physiology in Ukraine presented via webcam “Potential application of cerium dioxide nanoparticles for acute pneumonia treatment.” She and her team found that CeO2 nanoparticles significantly reduced morphological and functional pulmonary damage in rats after exposure to pneumonia. It was noted that Dr. Serebroska’s mother Dr. Tatiana Serebrovskaya, also a hypoxia researcher, was one of the first to suggest the role of nitric oxide as an important molecule in vasodilatory regulation.

Dr. Walter Calderon of the Hospital Nacional Ramiro Prialé, EsSalud, Huancayo, Junín, Perú and the Universidad Nacional del Centro del Perú, Huancayo, Perú presented “Prospective Validation of Framingham Criteria for Congestive Heart Failure diagnosis in a High Altitude Population” He noted that sensitivity was 98.6% for patients with Heart Failure, but specificity of these criteria were only 12% among patients who presented with dyspnea and at least one of the major Framingham criteria. He showed a compelling picture of collateral circulation from a cardiac cath.

Dr. Jose Antonio Carmona Suazo of the Hospital Juarez in Mexico presented “CO2 reactivity, a tool for prevention of HACE (High Altitude Cerebral Edema): Hands-on workshop.” He gave an exciting hands-on demonstration of the non-invasive and safe ability to monitor the level of  cerebral blood flow, ETCO2 in humans at altitude. Cerebral and respiratory effects were measured on Dr. Thuppil Venkatesh, who happily volunteered.

The Tiwanaku Código 0.4666 was presented by Willy Eduardo Cortez Hemzler, Investigador y Artista Plástico. Señor Cortez described how he discovered that the ratio of the length and width of the building materials at Tiwanaku equals 0.46, which is maintained throughout the structures. He showed the relationship of 0.46 to the radius of a circle.

After this, participants were treated to a bus tour of the city of La Paz.and the Inauguration Ceremony was held at the IPPA Building auditorium.

Inauguration ceremony, at the IPPA building auditorium. From Left (Prof. Thuppil Vnekatesh, The La Paz, Mayor's representative, Prof. Dr. Gustavo Zubieta-Calleja, Dra. Representative of the Colegio Medico, and Celeste representing Unifranz.

Inauguration ceremony, at the IPPA building auditorium. From Left (Prof. Thuppil Vnekatesh, The La Paz, Mayor’s representative, Prof. Dr. Gustavo Zubieta-Calleja, Dra. Representative of the Colegio Medico, and Celeste representing Unifranz.

It was a lively ceremony, with honored by the presence of 4 ambassadors (Great Britain, Mexico, European Union and Italy) and the representative of the Consulate of India, along with the representatives of the La Paz Medical College, Unifranz and the Bolivia. The La Paz Mayor’s office through its representative, granted Prof. Thuppil Venkatesh the “Huesped Ilustre de la ciudad de La Paz” (Distinguished Guest of the city of La Paz), normally given only to outstanding personalities (like Presidents) that visit our city.

Inauguration ceremony with the presence of 4 Ambassadors (England: James Thornton, Mexico: Hector Valezzi, European Union: Leon De la Barca and Italy: Placid Vigo, and also the representative of the Consul of India (Jorge Velasquez).

Inauguration ceremony with the presence of 4 Ambassadors (England: James Thornton, Mexico: Hector Valezzi, European Union: Leon De la Barca and Italy: Placid Vigo, and also the representative of the Consul of India (Jorge Velasquez).

Prof. Thuppil Vnelatesh with his Illustrious visitor award granted by the La Paz, Mayor's Office.

Prof. Thuppil Vnelatesh with his Illustrious visitor award granted by the La Paz, Mayor’s Office.

On Tuesday, October 11, participants left early in the morning to the ruins Tiwanaku and the Archaeological Museum, at 3800m. The morning provided a fascinating tour of the grounds of unknown age. Willy Eduardo Cortez Hemzler was the impromptu tour guide. The attendees also saw the big Monolito Bennet  at Tiwanaku, and visited the ruins of Punta Punku, believed to be even older than Tiawanaku.

Annie Wislowski, the writer of this follow-up, during the visit to Tiawanacu. (photo courtesy of Annie Wislowski)

Annie Wislowski, the writer of this follow-up, at the  Sun Door, during the visit to Tiawanacu. (photo courtesy of Annie Wislowski)

After this intriguing look at Bolivian history and life since ancient times at high altitude, participants had a late lunch on the Barco Multiproposito of the Bolivian Army. We were received in true elegance and style by the Army. Talks continued with Dr. Giuseppe Miserocchi continuing his presentation on “Inter-individual differences concerning the oxygen diffusion-transport function in the lung.” One fascinating thing we learned was that middle-distance runners tend to fare poorly at altitude, due to  increased permeability at the alveolar level!

Next, presented Rajashekar Nanjappa of the Regional General Manager, THE HINDI NEWSPAPER, Bengaluru, India Media & Mountain Medicine A Commitment: Role and Impact of Media on Society and with Special reference to Newspapers role in Public Awareness. He focused on the endeavors of LESAAT which has organized treks at high-altitude around the globe.

After these presentations, attendees returned to La Paz at Unifranz and viewed the poster competition entries. These were “Development and validation of new sepsis criteria at high altitude” by Dr. Walter Calderon-Gerstein, and “Spirometry values of high-rise residents” of La Paz, Bolivia by one of the medical students, both awarded the 100 US$ price donated by Prof. Thuppil Venkatesh, President of the International Society of Chronic Hypoxia.

Performing tests at the Titicaca Lake with Dr. Jose Antonio Carmona and Yeshua Peña Y Lillo (medical student working with Prof. Dr. Gustavo Zubieta-Calleja. (photo courtesy of Lucrecia De Urioste)

Performing tests at the Titicaca Lake with Dr. Jose Antonio Carmona and Yeshua Peña Y Lillo (medical student working with Prof. Dr. Gustavo Zubieta-Calleja. photo courtesy of Lucrecia De Urioste)

Measuring ETCO2, NIRS, brain waves and more with sophisticated technology brought by Dr. Jose Antonio Carmona for the Work Shop.

Measuring ETCO2, NIRS, brain waves and more with sophisticated technology brought by Dr. Jose Antonio Carmona for the Work Shop.

On Wednesday, October 12, participants rose early for the bus ride to Lake Titicaca at 3800m. Participants visited the High Altitude Diving Training Center in Tiquina.

Arrival to the Titicaca Lake

Arrival to the Titicaca Lake

Here, talks were given by the Comander of the Diving Center, Cap. Chavez who described in Spanish the history and workings of the Dive Center (CIBA) and the challenges encountered while diving at altitude (buceo en altura). After a delicious lunch tasting the high altitude lake trout, participants toured the hyperbaric chamber and the hospital boat located on the base.

The Commander of the High Altitude Diving Center of the Bolivian Navy givin a talk about their experience.

The Commander of the High Altitude Diving Center of the Bolivian Navy givin a talk about their experience.

Other talks that day included “Low Altitude Peripheral Edema (LAPE): The opposite of HAPE or HACE” by Prof. Dr. Gustavo Zubieta-Calleja, on the swelling (positive Godet sign) that occurs when high-altitude residents spend time in low-altitude environments. He described the changes in sialic acid levels obtained from red blood cells in his family after a trip to low-altitude destinations in India.

During the beautiful boat ride by the Bolivian Navy.

During the beautiful boat ride by the Bolivian Navy.

A pre-recorded lecture by Dr. Sadykova from the Institute of Mountain Physiology National Academy of Sciences, Kyrgyz Republic described the neuroendocrine changes occurring at altitude. Among those, elevated norepinephrine, dopamine, serotonin, TSH and T4, and a reduction of testosterone and T3 were noted.

Visiting the Hyperbaric Chamber at the CIBA, Bolivian Navy facilities.

Visiting the Hyperbaric Chamber at the CIBA, Bolivian Navy facilities.

KVR Tagore, President of LESAAT, then described “Mountains – Law – Ethics ,” and discussed the importance of protecting mountains as precious resources through sustainable tourism.

Finally, Willy Eduardo Cortez Hemzler took time to finish his lecture from Monday on Tiwanku and the code of 0.466.

After these presentations, attendees returned to La Paz at Unifranz and viewed the poster competition entries. Two  were granted the first prize of 100 US$ donated by Prof. Thuppil Venkatesh, President of the International Society of Chronic Hypoxia. These were: “Development and validation of new sepsis criteria at high altitude” by Dr. Walter Calderon-Gerstein, and “Spirometry values of high-rise residents” of La Paz, Bolivia by one of the medical students.

Hyaena Potosi Mountain near La Paz, (photo courtesy of Giuseppe MIsserochi)

Hyaena Potosi Mountain near La Paz, (photo courtesy of Giuseppe MIsserochi)

On Thursday, October 11, participants traveled initially to the Refugio of Huayna Potosi and later to Chacaltaya (5260m). Scores of llamas and alpacas were photographed by the curious attendees, some of whom even got to view a glimpse of the shy and reclusive vicuña!

Llama staring at the high altitude experts on their way to Chacaltaya. (photo courtesy of Giuseppe Misserochi)

Llama staring at the high altitude experts on their way to Chacaltaya. (photo courtesy of Giuseppe Misserochi)

In Chacaltaya, Nam Deo of Bangalore, India gave a talk “Vihangam Yog helps in high altitude chronic hypoxia” and led the group in meditation on the shoulder of the mountain.

The visit to Huayna Potosi and Chacaltaya

The visit to Huayna Potosi and Chacaltaya at 5300m

Interestingly, one of the participants reported that her pulse oximetry reading increased from 89% to 93% after the meditation session, Dr. Zubieta-Calleja, explained that as reported in one of his papers, breath holding at high altitude can momentarily increase the SpO2 to even sea level values of 98%.. Dr. Thuppil Venkatesh then gave a speech about “Life in high altitude conditions.” Prof. Sadashivaya, gave an interesting talk about the importance of “forestation at high altitude”. Prof. Nanjapa of the Hindu Newspaper talked about high altitude and the media, K.V.R Tagore talked about philosophical aspects of mountain climbing. Prof. Satish Jain also mentioned about his experience with high altitude.

Finally Prof. Dr. Gustavo Zubieta-Calleja, gave a talk about the evolution of high altitude medicine, the tolerance to hypoxia at high altitude and thanked everyone for participating in this outstanding symposium, where the visit to different altitude sights to show normally developing life is a one of the fundamental objectives of defeating the wrong concepts of hypoxia.

All these talks filmed outdoors with the Chacaltaya Pyramid “the highest laboratory in the world 5250m)” (shown in the background), created by the late Prof. Dr. Gustavo Zubieta-Castillo and his son Prof. Dr. Gustavo Zubieta-Calleja, in conjunction with the Club Andino Boliviano.

dsc_1308

Upon returning to La Paz, a dinner and closing ceremony was held at the residence of Prof. Dr. Gustavo Zubieta-Calleja in the southern residential area of Calacoto. It was a special gathering where Dr. Satish Jain assisted in preparing some food from India, along the food that Lucrecia De Urioste with her assistant, Lucia, Natalia and Rafaela so beautifully presented for all those attending. Some talks also took place here.

Closing dinner conferences

Closing dinner conferences

The Science, Honor and Truth Award, went this year to Prof. Kusal Das, being sent by Prof Thuppil Venkatesh.

The Science, Honor and Truth Award, went this year to Prof. Kusal Das, being given personally by Prof Thuppil Venkatesh on his return to India.

 

Conferences at the Closing Dinner.

Conferences at the Closing Dinner.

Dr. Giuseppe Misserochi presented Dr. Zubieta-Calleja with a gift of a water color painting of the Cordillera, that he personally painted while enjoying the beatufil mountains around La Paz.

Watercolor painting of the andes Cordillera by Prof. Misserochi.

Watercolor painting of the Andes Cordillera by Prof. Misserochi.

Nam Deo from India, leaded everyone in a meditation session in the living room.

Nam Deo's meditation session in the closing dinner.

Nam Deo’s meditation session in the closing dinner.

Awards and certificates were presented and the Symposium was closed.

Closing ceremony and birthday cake celebration. Dr. Satish Jain, Prof. Dr. Gustavo Zubieta-Calleja, Rafaela, Lucrecia De Urioste, Natalia, Dr. Walter Calderon

Closing ceremony and birthday cake celebration. Dr. Satish Jain, Prof. Dr. Gustavo Zubieta-Calleja, Rafaela, Lucrecia De Urioste, Natalia, Dr. Walter Calderon

The colleagues and friends from India, joined us in a trip to visit the incredible Salt Lake, Potosi and Sucre. Life at high altitude flourishes everywhere!

Prof. Giuseppe Misserochi pondering about the Salt Lake.

Prof. Giuseppe Misserochi pondering about the Salt Lake.

See you in the VII Chronic Hypoxia Symposium in two years!!

 

written by Annie Wislowski

Edited by Prof. Dr. Gustavo Zubieta-Calleja

La Paz1

Chronic Hypoxia Symposium VI

VI Chronic Hypoxia Symposium
Dedicated to the late Prof. Dr. Gustavo Zubieta-Castillo (Sr.)
                October 8-13, 2016
Mark your calendar! Visit our website.
 

We thank all the colleagues that have expressed their interest to participate.
 
New concepts about Chronic Hypoxia
 
We think that Chronic Hypoxia has to be looked upon in a different manner than how it is seen today. For anyone visiting us, you will find an active, busy modern city in the bowl shaped city of La Paz and El Alto. The streets are filled with people, in their daily routine, going up and down the streets, some quite steep.  How many are concerned that they are living between 4100m and 3100m? I could almost affirm: NONE. However some foreigners do feel the altitude as they are comparing it with sea level. But many of those start living here and adapt perfectly well. They also end up forgetting they are at high altitude!
City of La Paz 1

City of La Paz

City of La Paz

City of La Paz

The city of La Paz with much construction of buildings going on, lately.
How about sports at high altitude?
 
Some of you may recall the soccer game we carried out in the summit of Mountain Sajama at 6542m. under the leadership of Gustavo Zubieta-Castillo (Sr.)
Soccer at Sajama

Soccer at Sajama

Did you know that several  bicycle world speed records have been broken in La Paz? The lower density of the air is an advantage. Hypoxia is not a drawback.
bicycle racing

bicycle racing

 and how about the 100m dash?
The current men’s world record is 9.58 seconds, set by Jamaica’s Usain Bolt in 2009, while the women’s world record of 10.49 seconds set by American Florence Griffith-Joyner in 1988 remains unbroken.
 We think that the 100 meter dash world record could also be broken here!!!  Lets propose it and see if it is true. Falciform anemia, if by any chance present, could of course be a major drawback.
!00 meter Dash

!00 meter Dash

And about disease at high altitude?

 
We have to quote Dr. Thuppil Venkatesh, President of the Chronic Hypoxia Society: “I always keep thinking how two individuals (you and your Dad) with no resources could bring the world together to have a rethinking about the Physiology at High altitude as a way of life and not as sickness. you both.”.
We are naturally most thankful for his kind words.
We see the increase of red blood cells as a blessing, not a culprit. In fact we are happy when red blood cell counts increase. At high altitude, in our experience, anemia reduces your capacity for exercise, polycythemia does not. The most adequate terminology, as created by the late Gustavo Zubieta-Castillo (Sr). is Polyerythrocythemia.
Poly-erythro-cyt-hemia = Poly (many) + Erythro (red) + cyt (cells) + hemia (blood).
Can Chronic Hypoxia help in space travel and new settlements?
In our previous conferences we have proposed that space capsules have the same barometric pressure as La Paz (1/3 less than at sea level). This would help in energy resources, allow for longer travel, facilitate and speed the change of reducing pressure of the environment for the extravehicular suits to 1/3 of the sea level barometric pressure.
Space EVA 1

Space EVA 1

Space EVA

Space EVA

These are some of the advantages of chronic hypoxia.There are many more.
Are we (high altitude dwellers) afraid of life at sea level?
At high altitude, we are not afraid of mosquitoes and the risk of Dengue, Chikungunga or Zika. We don’t have them and they never disturb our sleep. That is wonderful!!!
Mosquito

Mosquito

In fact, we feel safe here at high altitude and we avoid going to low lands as we don’t want to put our health at risk.
Homage to the work of the late Gustavo Zubieta-Castillo Sr.
If you missed it,  you can read it here:
Interested in performing high altitude research?
Interested in performing research here in La Paz (3500m) in our labs at IPPA and/or Chacaltaya (5250m) at our pyramid laboratory two hours by car from La Paz? You could do it the week or two prior to the meeting. We will help you arrange it. A television network has expressed interest in recording this research at extreme altitudes.
Come join us and lets discuss all these concepts and many more. Express your ideas freely here in La Paz
See  you in October.
Prof. Dr. Gustavo Zubieta-Calleja
High Altitude Pulmonary and Pathology Institute IPPA

www.Altitudeclinic.com

Rio Soqueri 55
Final Av.Saavedra,Prologanciòn Av. Copacabana
Map:

La Paz, Bolivia

V Chronic Hypoxia Symposium news

Dear colleagues and hypoxia friends:

We will be hosting the V Chronic Hypoxia Symposium in Bolivia this October 6-11, 2014. Several outstanding scientists from around the globe will join us to discuss tolerance to hypoxia, and other aspects of hypoxia.  Among them we have Jan Marino Ramirez, Robert Naejle, Frantisek Kolar, S.V Srikrishna, Wolfgang Jelkmann, Thuppil Venkatesh, Praveen Sharma, Jain Neera, and several other outstanding scientists.   The setting is an itinerant symposium where we will carry out the conferences at different altitudes. If interested, please let us know. Our philosophy is that everyone can participate openly. Some months prior to the meeting we will post some questions regarding our themes  at ResearchGate.net  in order to carry out and develop a virtual discussion that will end at the meeting itself. All participants will be invited to post questions here (if they wish), prior to their presentation here in La Paz. This will certainly focus all of us on our subjects of interest in a dynamic way.
http://www/zuniv.net/symposium5

 

so, come join us!

V Chronic Hypoxia Symposium

Dear friends and colleagues around the world!


We are, once more, proud to announce the:

V Chronic Hypoxia Symposium

                October 6-11, 2014Mark your calendar!
Uyuni Salt Lake 3

click here to go to the Symposium website


Colleagues from many countries in the world are enthused and lined up to honor us with their presence.

It will once more be an itinerant symposium, where talks are given in different altitude sites. We will visit and have conferences at:La Paz 3510 m
Titicaca Lake, 3800 m
Tiahuanacu ruins 4000 m
Chacaltaya at 5230 m
and the Salt Lakes 3656 m


You will learn of “life at high altitude” in different environments.
And this time we are going to visit the famous Salt Lakes at 3656 m in the South of Bolivia (shown above).
Click here to read more about the Uyuni Salt lakes.
You will be completely impressed by the beauty of Bolivia and the hypoxic environment that is our “normal” everyday life.

click here to read about it.


During the V Chronic Hypoxia Symposium, we will have a meeting of the

International Society of Chronic Hypoxia.

It was created during the II Chronic Hypoxia Symposium


We will discuss about Life in Extreme Hypoxia and the

Tolerance to Hypoxia Formula.

Is it true that the paradox of going higher renders more tolerance to hypoxia?

Great scientists will join us in the analysis of these and other fascinating topics, so don’t loose the chance
by clicking here.



We are going to celebrate 44 years of scientific production in high altitude research..

Please read of our latest events and activities at:
http://altitudeclinic.com/blog/

All the best from Bolivia!!

Prof. Dr. Gustavo Zubieta-Calleja    and     Prof. Dr. Gustavo Zubieta-Castillo (Sr)….. still active

High Altitude Pulmonary and Pathology Institute
43 years of high altitude medicine
Web: AltitudeClinic.com
Email: zubieta@altitudeclinic.com
Phone: (591-2) 224-5394

budda

The Lung at High Altitude

The Lung at High Altitude: From cellular acclimatization to clinical disease

August 3-7, 2012
Leh, Ladakh, J&K, India

Prior to the Global Hypoxia Summit and 4th International Conference on Chronic Hypoxia held in India, the Leh Symposium was carried out under the direction of Dr. Qadar Pasha, the organizing secretary that efficiently carried this meeting. We were invited speakers thanks to Dr. QadarPasha and substantially Prof. Thuppil Venkatesh.

Opening ceremony Leh Symposium. From Left Ghazwan Butrous, Max Gassman, Sheila G. Haworth, Rajesh S. Gokhale, P. Tsering, Ghulam Mohammad

It was an atmosphere of science and friendship, with pleasant discussions on the many aspects motivating the search for knowledge in hypoxia. Leh is located at 3500 m of altitude quite similar to La Paz. It is over an hour flight from Dehli. I understand there are 27 flights per day so it is a very popular tourist destination.

And of course, where you experience hypoxia. The Pulmonary Vascular Research Institute (PVRI) also participated as coorganizer. Likewise, the Institute of Genomics and Integrative Biology under the direction of Dr. Rajesh S. Gokhale, based in Dehli and the Sonam Narboo Memorial Hospital in Leh, J&K, India with Dr. Ghulam Mohammad. He kindly had us visit the hospital premises.

Dr. Qadar Pasha Organizing Secretary during the Opening Ceremony

Several members of the PVRI were present including Ghazwan Butrous who recorded the conferences live and these will be available for the Fellows of the PVRI on their website. We again met Prof. Dr. Max Gassmann of the University of Zurich, Switzerland. He presented his work on Erythropoietin’ impact on exercise performance. Noteworthy was the presence of Dr. Sheila G. Haworth of the UK. She gave an intersting talk about surviving birht ath any altitude, Hypoxaemia to Normoxaemia. Prof. Thuppil Venkatesh, proposed a novel idea of gene mixing to improve human performance.

Zahara Ali, Venkatesh Thuppil, Donald A. McClain, Gustavo Zubieta-Castillo

Robert Naejle from Universite libre de Bruxelles, was very inquisite and critical about the presentations, which gave it a stimulating touch, that we personally greatly enjoyed! He talked about pulmonary disffusion  and exercise physiology. Jose Lopez-Barneo, from Spain gave an interesting talk about about the effects of chronic hypoxia on peripheral and central neurogenic centers. We also enjoyed the comments of Rubin Tuder from Denver Colorado. He talked about pulmonary vasculature and hypoxia signaling.  Hari S. Sharma gave a brief talk on Angiogenensis and tissue remodeling. Dr. Gabriel Diaz from the Universidad Nacional de Colombia, in Bogota, talked about the hyperreactivity of the pulmonary vascular tree. Anita Saxena from the All India Institute of Medical Sciences talked about the Eisenmenger syndrome.

Prof. Thuppil Venkatesh

We also made good friends with Uttam Patti, from the Nehru University who was presenting interesting work on hypoxia in cancer cells. And we also were plesantly surprised by the presence of our bolivina colleague Alexandra Heath from Kardiocentrum in La Paz, Bolivia. Her work on neonatal pulmonary circulation at high altitude was also very novel. We also heard some talks on CMS from Dr. Prakash, Negi, Dr. Norboo Angchuk and Dr. Tsering Norboo.

A relaxed moment between professors and students at a Buddist Temple.

Gustavo Zubieta-Castillo (Sr) gave a talk on Adaptation to life at the summit of Mt. Everest, adding new information to his hypopthesis. Gustavo Zubieta-Calleja (Jr), gave a conference on a complete novel concept: The Tolerance to Hypoxia Formula, affirming that the higher one goes, the more tolerance to hypoxia there is.

Zubieta-Castillo (Sr), Zubieta-Calleja (Jr) and Ghazman Butrous

taj majal

The Global Hypoxia Summit & 4th International Conference on Chronic Hypoxia

At the High Altitude Pulmonary and Pathology Institute (IPPA) we had three previous successful meetings of Chronic Hypoxia in La Paz: http://zuniv.net/symposium/follow-up.html http://zuniv.net/symposium2/follow-up http://zuniv.net/symposium3/ During the second symposium the International Society of Chronic Hypoxia (ISCH), was created. Thanks to the coordination of Prof. Thuppil Venkatesh from St. John’s University in Bangalore, we have carried out under the direction of Prof. Shashi Bala Singh, Director of Defense Institute of physiology and Allied Sciences (DIPAS), in New Dehli, India 9-12 August,2012, the GLOBAL HYPOXIA SUMMIT & 4TH INTERNATIONAL CONFERENCE ON CHRONIC HYPOXIA.

____, Air Marshal DP Joshi, Director General Armed Forces Medical Services, Dr. Vidyasagar Casikar, Neurosurgeon Australia, MM Pallam Raju, Minister of State for Defence, Gustavo Zubieta-Castillo IPPA, Prof. Shashi Bala Singh, Director DIPAS, Prof. Thuppil Venkatesh St.John’s University Bangalore, Gustavo Zubieta-Calleja (Jr) IPPA.

This has been a conference of interesting, stimulating and excellent presentations and discussions in a most friendly manner and at the highest level in search for “Promoting Quality of Health in Hypoxia”. Noteworthy was the presence of his excellency the Minister of State for Defense – Government of India M.M. Pallam Raju, who personally attended the opening ceremony and impressed us with his know-how as he is an Engineer keenly interested in scientific matters. The video of Dr. Zubieta’s speech is here Dr. Shashi Bala Singh Director of Dipas, focused on 4 types of approach: Physiological, Nutritional, Herbal and Technological. A unique blend in search of excellence.

Opening Ceremony lighting the candles, Dr. W. Selvamurthy, Minister of Sate for Defence M.M> Pallam Raju, Prof. Peter Barstch, Prof. Dr. Gustavo Zubieta-Castillo, Air Marshall DP Joshi, Dr. Lilly Ganju.

We, the Zubietas, had the pleasure of finding old friends such as Peter Bartsch, with whom we had spent wonderful moments, many years back during high altitude meetings and particularly one in Odessa, Ukraine when invited by a most disntinguished friend and colleague, Dr. Tatiana Serebrovskaya. We also met our dear friend Dr. Vidyasagar Casikar, We also had the please of establishing close friendship with Jan-Marino Ramirez, Nanduri R. Prabhakar, Benedito H. Machado. We also interacted with  Hari S. Sharma, Akpay Sarybaev, Uttam Pati, Zahid Ashraf, T. Norboo, Col G. Himashree, Anju Bansal, Nazan Dolu, Praveen Vats, AK Salhan, and many others with distinguished scientific presentations.

Opening ceremony. Cnl. G. Himashree, Dr. Shashi Bala Singh, Gustavo Zubieta-Castillo Sr.,Dr. W. Selvamurthy, Mr. MM Pallam Raju, Air Marshal DP Joshi, Dr. Peter Bartsch

The students also impressed us most favorably for the quality of their work, and we foresee an even greater scientific future for India. The scientific program can be found here. In the opening ceremony, Dr. W. Selvamurthy gave a most interesting work , with a resume of the scientific strategies used, based on research of the Indian Armed forces that perform operations at very high apoints including 6000m of altitude. He exclaimed “DRDO stands tall as a beacon for research in stressful environments in order to enhance the quality of life of the Man behind the Machine at high altitude”, a very stimulating and essential concept.

Receiving a scultured glass of remebrance from Prof. Kaushal K Sravastava and Prof. Akpay SArybaev after Prof. Dr. Gustavo Zubieta-Castillo’s (Sr) conference on Adaptation to Mt. Everest.

Dr. Shasi Bala Singh, in turn, commemorating the 50th anniversary of the Defense Institute of Physiology and Allied Sciences, in such an outstanding ocassion, expressed ” DIPAS has been working in the field of military physiology for the past fifty years with the primary mandate of promoting human performance in extreme performance”. From our point of view, this trip to India was extraordinary. The science, the friends, the philosophy, were all just great.

Analyzing high altitude aspects.

We would like to announce that the 5th Chronic Hypoxia International Conference will be held again in La Paz, Bolivia in October 2014. Please stay in touch for updates and development. Also, there will be a course on High Altitude Medicine, Physiology and Pathology on Feb-April 2013. Prof. Dr. Gustavo Zubieta-Calleja (Jr) and Prof. Dr. Gustavo Zubieta-Castillo (Sr)

Dr. Kamal from Nepal, Gustavo Sr., Gustavo Jr. and Prof. Nanhundiaha Shashidhara

Chacaltaya Pyramid

IV Chronic Hypoxia Symposium (Aug 2012 – India)

Chacaltaya Pyramid

The IV Chronic Hypoxia Symposium
August 9-12, 2012
in New Dehli, India

Please note that there is a last minute change in the date by the organizing committe in India.

Mark your calendar !

The website is at: http://www.hypoxiaresearch.in/Index.html

We are honored that this will be a grand scale meeting under the direction of
Dr Shashi Bala Singh,
Director of the Defence Institute of Physiology & Allied Sciences (DIPAS), Defense R  & D Organization
Min. Of Defense, Govt on India.

along with the coordination of:
Dr, Kaushal K. Srivastava
President. Dehli Chapter ACBI
National Coordinator for Professional Programme,ACBI.
Professor Emeritus, ACBR, Delhi University, Delhi 110007

and several other distinguished colleagues from the extraordinary India !!

 
        International Scientific Committee

 

Prof. Dr. Gustavo Zubieta-Calleja (Chairman)

Director of the High Altitude Pulmonary and Pathology Institute
Vice-President of the International Society of Chronic Hypoxia
Web: AltitudeClinic.com

Email: zubieta@altitudeclinic.com
Av. Saavedra 2302
La Paz, Bolivia

Phone: (591)- 73258026


Prof. Dr. Gustavo Zubieta-Castillo

Honorary Director of the High Altitude Pulmonary and Pathology Institute
Scientist, Literate, philosopher
Web: AltitudeClinic.com

Email: zubieta@altitudeclinic.com
Av. Saavedra 2302
La Paz, Bolivia

Phone: (591-2) 224-5394



Dr Thuppil Venkatesh

Principal Advisor Quality Council of India (QCI) &
National Referral Centre for Lead Poisoning in India (NRCLPI)
Professor- Department of Biochemistry & Biophysics
St. John’s Medical College
Residence: 00-91-80-2553 2146
Work: 00-91-80-2206 5058/2206 5050
Fax: 00-91-80-25502341
Cell: 00-91-93412 42430
venkatesh.thuppil@gmail.com
India


Dr. Larry Silver, MD
President
International Society of Chronic Hypoxia

PO Box 8432
Truckee, CA 96162
530 550-0234

USA


Prof. Poul-Erik Paulev

University of Copenhagen, Denmark
e-mail: pepaulev@yahoo.dk
Tel: 45 45 813271
Denmark


Dr J. N. Mehrishi, PhD (Cantab.) FRCPath.

Director
The Cambridge Blood, Stem Cells, Spermatozoa and Opioid Research Initiatives-Blood Doping and High Altitude Research
The Cambridge Chronic Hepatitis , HIV/AIDS New Treatment Strategy Development Initiative
Convener/Coordinator:
The Cambridge-Budapest-Paris-Cologne-Bonn-Guangzhou Hepatitis, HIV/ AIDS Research Study Group
Macfarlane Cl. 13, Impington, Cambridge CB24 9LZ, United Kingdom.
Tel 44-1223-57 36 28.
Fax: 4(By arrangement only)
jm45@cam.ac.uk

UK


Tatiana V. Serebrovska(Serebrovskaya, Serebrovskaia, Serebrovs’ka -dif.spellings)
Professor of Physiology, Doctor of Biology, Ph.D.
Academician of Int. Acad. Sci.
Principal Researcher of the
Bogomoletz Institute of Physiology
4 Bogomoletz St.
Kiev 01024, UKRAINE
Tel: (38-044) 256-2557 (o); 411-6590 (h)
Fax: (38-044) 256-2000
e-mail: sereb@biph.kiev.ua (o)
tsereb@voliacable.com (h)

Ukraine


Dr. Marcus Ranney  MBBS BSc (Hons) (LON)

Strategy and Business Development Manager,
Khubchandani Healthcare Ltd,
Mumbai

Address is also no longer valid as I know live and work in India

Email: docmranney@gmail.com
e-mail: marcusranney@hotmail.com
Mobile: 0091 9820416787 (Bombay)


Prof. Robert Naeije

Professor of physiology and medicine
Free University of Brussels

rnaeije@ulb.ac.be
Belgium


 

Dra. Elydia Mujica Albán.Director of Research Unit.
Principal Researcher of National Institute of Andean Biology.

Professor and Physiology Section Chief

Faculty of Medicine – UNMSM

Lima – Peru.

Phone: (511) 4492597, (511) 4260244

Mobile: (511) 999712171; 
e-mail: elymujica@yahoo.es
           emujicaa@unmsm.edu.pe
Peru


Prof. Vidyasagar Casikar

Neurosurgery
casikarv@gmail.com

Sydney, Australia


Natalia Zubieta
Director
High Altitude Museum
La Paz, Bolivia
email: high.altitude.museum@gmail.com
Av. Saavedra 2302
La Paz, Bolivia
Phone: (591-2) 224-5394

Bolivia


Dr. Buddha Basnyat
Director Nepal International Clinic
Medical Direcgtor of the Himalayan Rescue Association
President of the UIAA medical commission
rishibas@wlink.com.np
Kathmandu, Nepal


Dr. Frantisek Kolar
Institute of Physiology
Academy of Sciences of the Czech Republic

kolar@biomed.cas.cz
Prague, Czech Republic


Remember, we are a different kind of symposium. We are open to any presentation. We don’t reject anyone. Everyone has an opportunity to express their ideas. Many great ideas are buried due to peer reviewers and groups that only publish their teams and reject others in spite of their great talent and production. But talent and creation are like an unsinkable buoy. They always surface even if you try to keep them underwater.


 



At IPPA we are going to celebrate 42nd Anniversary, next year.

Please read of our latest events and activities at:
http://altitudeclinic.com/blog/

All the best from Bolivia.

Prof. Dr. Gustavo Zubieta-Calleja    and     Prof. Dr. Gustavo Zubieta-Castillo (Sr)….. still active

High Altitude Pulmonary and Pathology Institute
Web: AltitudeClinic.com
Email: zubieta@altitudeclinic.com
Phone: (591-2) 224-5394

Chronic Hypoxia Symposium IV

Dear colleagues from around the world:

After 3 successful Chronic Hypoxia Symposiums held in La Paz, Bolivia, we are very proud to announce that the IV Chronic Hypoxia Symposium will be held in India under the direction of Prof. Thuppil Venkatesh.

Please stayed tunned for the preliminaries that will soon surface.

In the meantime, we want to thank all those that participated and attended our III Chronic Hypoxia Symposium held in La Paz in Oct 2010. Our President Larry Silver was able to find support from CISCO that transmitted via Webex to all the participants  live presentations from around the world.

Gustavo Zubieta-Calleja
Vice-President
International Society of Chronic Hypoxia